Welcome to our HEp-2 atlas




 
To find a pattern, please do one of the following:

u

   you know the pattern you want to see; just browse the table below and click on this pattern.

u

   you know the pattern category you want to see (e.g. nuclear-speckled); just browse the table below and click on this category.

u

   you do not know where to look; browse  the page banner and select a range of patterns (e.g. nucleolar)
  
Nuclear patterns
1. homogeneous
 
  homogeneous double arrow  DNA, histones
  homogeneous / peripheral  DNA, histones
 
2. nuclear membrane
 
  homogeneous lamin
  annular with nuclear necklace   nuclear pores
  annular with mitotic pattern     perichromin
 
3. speckled
  large or coarse speckles RNP
  fine speckles SL / Mi
  flat speckled, "frosted glass"   SS-B
  fine speckled  SS-A
  irregular PCNA
  23 or 46 speckles centromere
  2 - 4 speckles NSP1 - nuclear dots
  5 - 10 speckles NSP1 - multiple dots
  5 - 10 grains    NSP1 - multiple dots
 
Cytoplasmic patterns
1. speckled 
 
  large speckles mitochondrial
  fine speckles  SRP
  perinuclear  Jo-1
  perinuclear endoplasmic reticulum
  fine and dense speckles   ribosomal
  cytoplasmic and/or nuclear dots     protein synthesis site
 
2. fibrous
 
  spiderweb actin
  short, bristled fibers at the cell periphery tropomyosin
  honeycomb cytokeratin
  coils vimentin
  spines along the cell membrane vinculin
 
3. organelles (rare)
 
  lamellas close to one pole Golgi
  vacuoles lysosomes
 

Nucleolar patterns

  homogeneous PM/Scl
  clumpy fibrillarin
  speckled  Scl70
  multiple dots NOR
 

Mitotic patterns

   chromosomal staining in all phases chromosomal coating protein
  centrioles

  triangular fluorescence at the poles   NuMA or MSA-1

  telophase: strong staining at cell junction MSA-2

  metaphase: 2 rows of speckles   MSA-3
  fibers  tubulin

 Last revision: 03-09-10